Protein Details: Potassium channel subfamily K member 18

Protein ID

ICDB_Pro_1182

Protein Name

Potassium channel subfamily K member 18

Gene Name

KCNK18; TRESK; TRIK

Organism

Homo sapiens (Human)

Length

384 amino acids

AlphaFoldDB

AF-Q7Z418-F1-model_v4.pdb

Function

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin;whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics;such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool;an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity).

Sequence

MEVSGHPQARRCCPEALGKLFPGLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEKFLEELCRILNCSETVVEDRKQDLQGHLQKVKPQWFNRTTHWSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPNFFLFFSIYIIVGMEIVFIAFKLVQNRLIDIYKNVMLFFAKGKFYHLVKK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Migraine With Aura 13 and Familial Hemiplegic Migraine

Location

Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.

DOI ID

10.1074/jbc.m206810200; 10.1038/nature02462; 10.1213/01.ane.0000136849.07384.44; 10.1113/jphysiol.2007.145649; 10.1016/j.bbrc.2009.12.056; 10.1038/nm.2216

RefSeq

NP_862823.1